Sentence examples for improvement of compound from inspiring English sources

It is clear that the improvement of compound quality accelerates the drug discovery projects.

Improvement of compound 13 hydrophobic character by addition of an aromatic ring substituent resulted in entropic optimization, reflected on a thermodynamic discrimination profile characteristic of high affinity ligands.

Thus, there should be significant potential for further improvement of compound optimization efforts by taking activity cliff information from data mining into consideration.

These findings provide guidance for the design and improvement of compounds with DAT activity, which is important for the development of a treatment of cocaine addiction and certain neurological disorders.

Maintenance of the safety and integrity of sterile compounded drugs in the United States demands a thorough review and improvement of compounding pharmacy regulatory practices.

LC-MS identification of a mono-hydroxylated metabolite found in the RLM incubation of 4 3 provided an impetus for further improvement of the compound.

Moreover, electron probe micro-analyses confirmed that the good Tc and Bc2 were the result of the qualitative improvement of the Nb3Sn compound based on the effects of arranging the Nb filaments radially, increasing the ratio of Sn-to-Nb and shortening the diffusion length for Sn.

These results demonstrated that metabolic profiling analysis could be successfully applied to the rational guidance of medium optimization and the productivity improvement of value-added compounds.

The qualitative and quantitative improvement of biologically active compounds by plant cell, tissue and organ culture have been used as an alternative source for the production of important bioactive secondary metabolites using different strategies of metabolic engineering.

The results indicated that extension at the 3-position resulted in loss of activity compared to the original compound I. On the other hand, extension at the 6-position resulted in improvement of activity in the compound cis-12 by 2-fold over the parent compound I indicating favorable interaction.

Accordingly, a major goal for the improvement of a lead medicinal compound is receptor-affinity maturation.