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Fastener holes in aircraft components are routinely cold expanded to improve fatigue life, although the precise level of improvement is difficult to quantify.
In principle, an enormous number of process options can be generated but where and how the process should be intensified for the biggest improvement is difficult to identify.
As no amitriptyline blood concentrations were reported, establishing causality for clinical improvement is difficult [ 14].
Due to the design with two consecutive samples of sickness certificates, a causal relationship between the implementation of the guidelines and the quality improvement is difficult to establish.
We recognize that assigning an economic value for survival improvement is difficult regardless of how small the differences in clinical benefit are.
Functional improvement is difficult to achieve in the challenging TNF-α-refractory group by virtue of probable secondary damage that would be incurred; the ATTAIN study is notable for the statistically greater benefits in physical function (defined by improvement in HAQ-Disability Index of at least 0.3) seen (by day 15) in the abatacept-treated group, which was sustained at 2 years [ 29, 30].
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This implies that shortcomings and room for improvement are difficult to identify [ 10].
An expected outcome would be an improvement in ethanol productivity, although this improvement was difficult to quantify in our work due to the absence of ethanol production by strain TMB3400 and the parental strain in xylose batch cultures (Table 3).
The authors caution, however, that measuring small visual improvements is difficult and that they can't say for sure that the changes were not the result of the immune-suppressing drugs or a placebo effect.
She said: "Merging three separate prisons into one massive establishment has created a prison that, despite some improvements, is difficult to manage, unsafe in parts, with poor conditions in others and a lack of proper provision for education, training and work overall.
The authors previously described a rehabilitation programme integrating exercise and self-management [Enabling Self-management and Coping with Arthritic knee Pain through Exercise (ESCAPE-knee pain)] that produced short-term improvements in pain and physical function, but sustaining these improvements is difficult.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com