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Alternatively, antisocial participants need to be screened out of CBT interventions that aim primarily to target core ADHD symptoms of attention, impulsivity, planning and organization deficits, else it is possible that improvement in functioning in these domains may be applied to improve antisocial skills.
Given the potential for functional burden that ADHD may place on children and adolescents, an improvement in functioning in these areas is of great value both to patients and their caregivers [ 17].
Results demonstrated statistically significant improvement in functioning among patients on lurasidone monotherapy compared to placebo.
Improvement in functioning among patients on lurasidone was largely mediated through a reduction in depression symptoms, but lurasidone also had a medium and statistically significant independent direct effect in improving functioning.
The results show an overall improvement in functioning over the study period across the whole cohort.
Also, more than half of the subjects with depressive and manic/mixed symptoms achieved a significant improvement in functioning.
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Those patients administered progesterone experienced significant improvements in functioning outcome, indicating neuroprotective properties of progesterone in acute severe TBI.
Significant improvements in functioning across a range of other secondary outcomes were observed which were maintained at follow-up.
Cardiac defects in both pathology and functions in the P448L mice are limited and significant improvement in function is difficult to demonstrate even with effective AAV9 gene therapy14.
For two of the proteins (CyoB and CydB), we conducted functional assays to confirm that the increase in protein expression also led to phenotypic improvement in function.
But even a minor improvement in function would be of huge benefit.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com