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Improved tolerability with lixisenatide was reflected by the fact that more lixisenatide-treated subjects tolerated the target dose of 20 µg/day.
A rationale for combined phentermine/topiramate for BED and BN is improved tolerability and efficacy.
Second-generation antipsychotics were developed with the promise of enhanced efficacy and improved tolerability relative to their first-generation predecessors.
These AEDs (except felbamate) offer appreciable advantages in terms of their favorable pharmacokinetics, improved tolerability and lower potential for drug interactions.
Modern subunit vaccines have excellent safety profiles and improved tolerability, but do not elicit strong immune responses without the addition of adjuvants.
Compared to combination regimens, sequential single-agent chemotherapy provides similar efficacy and improved tolerability and may represent the preferred option for most patients.
The second-generation ABCB1 inhibitors, such as valspodar/PSC-833 and biricodar/VX-710, had improved tolerability compared to the first-generation compounds.
Alternatively, targeting of vaccines directly to large populations of skin immune cells holds great potential in achieving protection, with significant dose sparing and improved tolerability profiles.
This suggests improved tolerability after repeated dosing.
There is further evidence to support improved tolerability with fosphenytoin.
Conclusively, HDM SCIT provided improved tolerability to HDM allergens in skin and lungs.
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