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The overall outcome of septic shock has clearly improved over the recent years, related to improved supportive care and rapid and protocolized treatment interventions supported by international guidelines [ 8].
The incorporation of novel therapeutic agents such as immunomodulators (thalidomide, lenalidomide and pomalidomide) and proteasome inhibitors (bortezomib and carfilzomib) as well as improved supportive care options have led to significant improvements in the OS of patients with MM.
Central nervous system (CNS) tumors have the second highest frequency of all childhood cancers. 1 With advances in neurosurgery, radiotherapy techniques, the use of combination chemotherapy, and improved supportive care, the last 40 years have witnessed a significant improvement in the survival of these children.
Hopefully improved supportive techniques, methods to predict patients who will develop ARDS and the recognition that large well designed multi-centre trials will be required will lead to the emergence of specific and effective pharmacotherapies.
However, recent insights into the biology of haploidentical transplantation, the availability of effective in vivo large-scale graft-manipulation technology, and improved supportive care strategies have led to and are still leading to significantly better outcomes compared to previous decades.
This is likely to be because of earlier diagnosis, standardisation of treatment, treatment in specialist centres and improved supportive care.
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There is sufficient evidence to support the use of body composition assessment to direct and improve supportive oncological care such as dietary intervention and physiotherapy support.
In 2004, the National Institute for Clinical Excellence NICEE) identified social support as one of the main topic areas for improving supportive and palliative care for adults with cancer.
Identifying these determinants could improve supportive community care for the terminally ill.
Incentives include introducing or improving supportive supervision, performance appraisal, responsive options for careerdevelopment and more transparent promotion processes [ 25].
In oncological settings, recent projects as "Supporting transmural oncological care" [ 59] and "Integrated care" [ 60] revealed that supportive care coordination improves supportive care delivery in cancer patients.
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