Exact(4)
The resulting improved substitution tables could then be used to realign the sequences.
Thus choosing a codon model over a singlet model involves a tradeoff between a substantially improved substitution model and a possibility of incorrect homology in the alignment.
Because the effects of the latter can be significant when the total number of substitutions is small, we welcome the development of an improved substitution model that does not force this tradeoff.
The analysis of the state of the art in the field reveals the presence of innovative techniques for scaffold and material manufacturing that are currently opening the way to the preparation of biomimetic substrates that modulate cell interaction for improved substitution, restoration, retention or enhancement of bone tissue function.
Similar(56)
Attempts at improving substitution matrices for database searching, take these forms of substitution heterogeneity into account with the development of position-specific scoring matrices [ 3], profile-based methods [ 11], hidden Markov models [ 12] and structure-specific substitution matrices [ 13].
Inhibitors with small side chains at C-6 were generally well tolerated by the enzyme, and the physicochemical properties of the inhibitors were improved by substitution of a small alkyl group at this position.
The power SS-based method improved the substitution and deletion error rates but degraded the insertion error rate compared with CMN.
Regions corresponding to SVRs were identified in PB alignments and were realigned (17) by a modified CLUSTALW (22) algorithm using a recently improved PB substitution matrix (27).
Substitution (S) is called an improving substitution for (P) if applying (S) to (P) preserves the set of satisfiable instances, that is, if (lfloor S P rfloor = lfloor P rfloor ).
Innovative wood technologies can improve the substitution effects considerably and should become a substantial component in improving the mitigation potential of HWPs.
It was found that the acid recovery rate was improved by benzyl substitution, while the selectivity improved by aryl substitution.
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