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The introduction of interferon-γ assays has improved specificity for detecting LTBI compared with the tuberculin skin test [ 15, 16].
Monoclonal antibodies to carcinoembryonic antigen (CEA) promise improved specificity for the measurement of this widely expressed human cancer antigen.
Combining markers enabled improved sensitivity for non-jaundiced PDAC patients over HCs and improved specificity for jaundiced PDAC patients over jaundiced benign disease subjects.
For CIN2+ as well as CIN3+, that study also found an improved specificity for p16 cytology compared with HPV testing (for CIN2+, 50.7% vs 23.3%).
In summary, based on crystallographic data we have isolated two variant forms of cADO that were strategically engineered to display improved specificity for short- to medium-chain aldehydes.
A double-antibody sandwich ELISA was developed as it was previously shown to have improved specificity for a target cellulase enzyme present in a cellulase enzyme mixture.
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A thioesterase with altered specificity added to the strain improves specificity for specific fatty acid chain lengths.
Future improvements will include the incorporation of targeted imaging contrast agents to improve specificity for imaging tumours.
A series of pyrazolo-pyrido-diazepine dione analogs demonstrated to be particularly amenable to lead optimization through a couple of cycles in order to improve specificity for isoforms Nox4 and Nox1 and had excellent pharmacokinetic parameters by oral route.
Therefore, to improve specificity for active kala-azar case confirmation, we used an alternative cutoff of 10 standard deviations (strong seropositive) for 2002 serosurvey data.
In accordance to earlier reports, by combining CRP and WCC measurements we could not further improve specificity for the diagnosis of bacteremia [ 6, 25].
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