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Improved specificity and diagnostic capability can be achieved by developing assays that detect cancer-specific alterations of glycoprotein glycosylation.
The combination of Presepsin and PCT significantly improved specificity and PPV (Table 4).
However, Cas9 orthologues and engineered Cas9 variants offer expanded genome targeting capabilities, improved specificity and biochemical properties.
However, indexing significantly improved specificity and accuracy of visual scores, such that indexed visual scores were statistically equivalent to all other methods.
The successful development of several nano-assembly-based polymer therapeutics further encouraged scientists to develop nano-vehicles to achieve controlled release, enhanced efficacy, improved specificity and reduced toxicity.
After 3-mercaptopropionic acid (MPA) self-assembled monolayers (SAMs) modification, the Au-RMEs obtain improved specificity and sensitivity for monitoring of dopamine (DA) with respect to alleviating ascorbic acid (AA) interference.
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Structure-based site-directed mutagenesis is usually applied to produce variants with dramatically improved specificities and the residues in or near the active site tend to be chosen as their special roles in the activity of the enzymes [ 21- 23].
ADC values are also helpful in improving specificity and confidence levels.
Batch PEGylation reaction methods are discussed, along with innovative methods using packed bed or "on-column" approaches to improve specificity and yield.
Alternative chemistries of ASOs are also being pursued by many investigators to improve specificity and antisense efficacy and to reduce toxicity.
This protocol is an alternative to replace current STRs monoplex genotyping techniques; it permits the optimization of resources, improving specificity and sensitivity compared with common methods used to typify this parasite.
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