Age-specific reference ranges improved specificity in older men (49%) but decreased sensitivity (70%), with an LR+ of 1.38.
The intervention's odds of improving residents' diagnostic impression were significant (OR = 2.2; 95% CI = 1.3-3.6), with significant improvement in sensitivity (p = 0.02) and a trend toward improved specificity.
Improved specificity and diagnostic capability can be achieved by developing assays that detect cancer-specific alterations of glycoprotein glycosylation.
Dobosy, J. R. et al. RNase H-dependent PCR (rhPCR): improved specificity and single nucleotide polymorphism detection using blocked cleavable primers.
This indicates comparable sensitivity and improved specificity of the cardiac microtissue compared to monolayer approaches, illustrating that cardiac microtissues are an applicable model system.
This mutant scFv demonstrates improved specificity compared to the wild-type recombinant antibody, indicating an important role for Asp101.
However, Cas9 orthologues and engineered Cas9 variants offer expanded genome targeting capabilities, improved specificity and biochemical properties.
LwaCas13a can be heterologously expressed in mammalian and plant cells for targeted knockdown of either reporter or endogenous transcripts with comparable levels of knockdown as RNA interference and improved specificity.
The combination of Presepsin and PCT significantly improved specificity and PPV (Table 4).
The combination of Presepsin and PCT improved specificity, NPV and PPV reaching up to 97%%.
The pediatric pseudo-control group dramatically improved specificity (97% vs. 89%; p < 0.0001) by increasing the positive predictive value (86% vs. 65%).
