The major goal of this project is to test a new Merck compound in a mouse model of narcolepsy to determine if it improves sleepiness and cataplexy.
Last week research from the Mayo Clinic in Arizona, published in the journal Sleep, suggested, not at all radically, that turning down the light on these devices could reduce melatonin suppression and improve sleepiness.
To our knowledge, only one published study has examined the impact of PAP therapy on the daytime functioning in children with OSA; Marcus and colleagues demonstrated improved daytime sleepiness after 6 months of PAP treatment, but no change in other functional outcomes, including behavior, temperament, and school performance [5].
Levothyroxine improves subjective sleepiness in a euthyroid patient with narcolepsy without cataplexy.
Both the DA and exercise training treatments did not improve daily sleepiness levels, confirming previous data [ 2, 10] however, the majority of the patients had scored below the cutoff point (>10.0) that declare severe daily sleepiness.
Secondary hypotheses for the main trial include: "Education for primary care teams in problem focused therapy for patients presenting to primary care with insomnia improves daytime sleepiness, anxiety and depression, health-related quality of life and reduces hypnotic use, adverse effects and costs compared to treatment as usual including sleep hygiene".
In a separate study among adolescents [ 26], a delay of school start time by 30 minutes led to an increase in sleep time by 45 minutes; more satisfaction with sleep; improved motivation; reduced sleepiness, fatigue and depressed mood; and improved class attendance.
The cough and sleepiness improved significantly with nocturnal nasal CPAP after 2 days and the cough resolved completely 3 months later.
Daytime sleepiness improved in the lurasidone and placebo-treated groups but worsened in the quetiapine XR treatment group when compared to placebo (p = 0.001) and to either dose of lurasidone (both p < 0.01).
Another study, published in The Journal of Biological Rhythms, found that after exposure to blue light, younger subjects had increased alertness, decreased sleepiness and improved mood, whereas older subjects felt none of these effects.
