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Results showed that genistein effectively improved serum and hepatic lipid metabolism and diminished fat accumulation in liver.
However, aripiprazole improved serum prolactin level in some participants and overall did not show any adverse effect on QTc interval.
It also improved serum insulin levels, β cell function, reduced insulin resistance and restored pancreatic beta cells compared to the diabetic group.
Pravastatin therapy significantly improved serum oxidation lag time (+8%, P<0.05), maximal diene formation rate (−22%, P<0.01) and total amount of dienes formed after 5 h (−16%, P<0.01).
Although both nanostructures showed prolonged action profiles and improved serum stability compared to the parent peptide, the morphology of the nanostructures is highly critical to manipulate the release profile of the free peptide from the assembly and regulate their bioactivity.
Nanoparticle-based drug delivery is on the verge of revolutionizing cancer therapy due to superior drug solubility, improved serum stability, longer circulation half-lives, better drug loading and shielding ability, and excellent drug accumulation in tumor through the enhanced permeability and retention effect (Brigger et al. 2002; Petros and DeSimone 2010).
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A fluorenylmethoxycarbonyl sulfonic acid (FMS) derivative of the 6-aminoquinazoline analog of AG1478, which was designed to have improved serum-binding properties, was shown by fluorescence analysis to bind with approximately 100-fold greater affinity than the parent compound.
14, 15 Small pilot uncontrolled studies showed beneficial effects of ezetimibe in improving serum ALT, AST, and liver fat by ultrasound and showed improvement in liver histology in a diverse group of patients with NAFLD as well as NASH.
Dietary intervention for improving serum lipids emphasizes on dietary fiber, plant protein, and flavonoids.
Recombinant human GH (rhGH) treatment of pituitary GHD improves serum levels of leptin, adiponectin and C-reactive protein (CRP).
Conclusion: Zinc supplementation is an effective means of improving serum levels of zinc and cholesterol in the HD patient.
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