Sentence examples for improved secretion from inspiring English sources
Using site-directed mutagenesis of native SGSH, we identified an improved secretion variant that also displayed enhanced uptake properties that were mannose-6-phosphate receptor independent.
We also demonstrated improved secretion clearance in patients during CLR that were unrelated to P&PD.
Acutely, improved secretion clearance might be responsible for the reported decrease in pneumonia during prolonged use of CLR [ 5, 6, 7, 8].
Thus, amino acid replacements selected to improve the thermodynamic properties of 2C, also improved secretion of 4B2A1 as well as 7A10B2.
Here we demonstrate that the bridge improved secretion of correctly folded cTCR-cIg molecules two (7A10B2) and five (4B2A1) fold, respectively, for murine TCRs.
All molecules were initially poorly secreted from eukaryotic cells, but replacement of unfavourable amino acids in the V regions improved secretion, as did the introduction of a disulfide bridge between the TCR C domains and the removal of an unpaired cysteine.
Furthermore, we demonstrated that the engineered intein dramatically improves secretion of scFv-intein fusion proteins from yeast and, since the secreted proteins are folded and active, the scFvs can be directly functionalized and site-specifically immobilized via EPL and click chemistry.
Depolarization of the membrane with 50 mM K+ in the presence of high glucose did not significantly improve secretion.
This suggests that placing strong hydrophobic amino acid residues in the signal peptide are required for the secretion of a recombinant protein, but the composition of amino acids in the h-domain is more critical than merely increasing total hydrophobicity to improve secretion of recombinant proteins.
In order to improve secretion of recombinant proteins in E. coli expression systems, a number of heterologous signal peptides have been evaluated (Velaithan et al. 2014; Jonet et al. 2012; Ismail et al. 2011; Low et al. 2011; Nagano and Masuda 2014).
The results showed that M105I mutant had a dose-dependent inhibitory effect on exocytosis, whereas, in the same range of concentrations, the wild type protein could even improve secretion (Fig. 8A).
