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Since transcriptome analysis only provides snapshots of the gene expression state in cells constituting the tissue at study, clear improvements in diagnostic accuracy or clinical endpoints (e.g., improved recurrence free survival) must be objectively shown before the results of such studies can be safely implemented in the clinical armamentarium.
Moreover, a low density of CD68-positive cells in TIF correlated with a significantly improved recurrence free survival.
The appearance of autoantibodies or autoimmune manifestations in IFN-treated patients has been reported to be associated with significantly improved recurrence free and overall survival [ 4].
Wegman et al observed, in contrast to Goetz et al, that patients homozygous for CYP3A5*3 have improved recurrence free-survival [ 18, 25].
A validation study confirmed these findings and demonstrated that HMG-CoAR was an independent prognostic marker, associated with an improved recurrence free survival (RFS) [ 14].
The psychological intervention by Andersen [ 87] reported that survival at 11 years was improved (recurrence hazards ratio [HR] of 0.55; P = 0.034) and death from breast cancer (HR of 0.44; P = 0.016) in addition to improved well-being and compliance with medication.
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After 3 years of follow-up, docetaxel significantly improved recurrence-free survival compared to vinorelbine without improvement in survival.
Targeted therapies such as Herceptin and Lapatinib have improved recurrence-free survival and helped control metastatic or recurrent disease (as reviewed [ 1]).
Lymphocyte infiltrate (HR 0.37, 95% CI 0.19 0.72, P=0.003) was significantly associated with improved recurrence-free survival.
Colon cancer patients treated with both IFN- α and 5-FU showed a trend towards improved recurrence-free survival [ 12].
Multivariate analyses revealed response to neoadjuvant chemotherapy highly significant correlated to improved recurrence-free survival (p = 0.002) and overall survival (p = 0.017).
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