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In Phase IIb study, compared to placebo, famitinib showed significantly improved progression free survival (PFS) in patients with advanced colorectal cancer while its toxicity was manageable [16 18].
AURELIA, a randomized phase III trial of adding bevacizumab (B) to single agent chemotherapy (CT) for the treatment of platinum-resistant recurrent ovarian cancer, demonstrated improved progression free survival (PFS) in the B+CT arm compared to CT alone.
Patients exhibiting these responses show an significantly improved progression free survival.
Analysis of the secondary endpoint of improved progression free survival will take into account patient stage subgroups.
Apatinib, inhibitor of VEGF-2, showed improved progression free survival and overall survival in heavily pretreated patients with metastatic gastric cancer in phase II trial [ 40].
From our immune monitoring data, mentioned below, we might not only conclude that the presence of tetramer-specific T cells is correlated with an improved progression free survival.
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When combined with cisplatin and gemcitabine (AVAiL study) in NSCLC, bevacizumab showed no improvement in overall survival, but demonstrated improved progression-free survival (Reck et al, 2010).
Nevertheless, evidence has shown improved progression-free survival with en bloc resection for certain low-grade malignant and aggressive benign musculoskeletal tumors.
The study closed prematurely and was likely underpowered, but in the chemotherapy arm, a trend toward improved progression-free survival and overall survival was shown.
Only trametinib (see above) showed improved progression-free and overall survival both as a single agent and in combination with the BRAF inhibitor, dabrafenib [28 30].
We next identified the CpG site specific and regional methylation patterns most predictive of gene silencing and improved progression-free survival.
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