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Current device developments for oral CM include improved probe design.
An improved probe technique for the measurement of bubble size and velocity in turbulent bubble dispersion has been developed.
This method provides AFM users improved probe quality and practical guidelines for customized probes, which can support the development of novel scanning probe microscopy (SPM) applications.
An improved probe design, based on the nearest neighbor model for nucleic acid-probe duplex stability, resulted in a better separation (ΔTm ∼ 10°C) of melting peaks of the wild-type and mutant alleles than that by the existing method (ΔTm ∼ 3°C) for specimens heterozygous for the 1298A>C polymorphism.
Hence, samples in the post-globin reduction group showed improved probe detection and reduced intra-group detection call variance with respect to those in the pre-globin reduction group (Figure 1A).
In FISH analysis, use of thinner sections enables improved probe penetration and better signal visualization.
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Characterization of probe pharmacokinetics and metabolic stability is critical for understanding in vivo performance and to develop improved probes.
After performing this random re-association for each blood sample, we applied the same criteria for selecting significantly improved probes as was applied to the observed data, and recorded the number of probes that passed the selection criteria.
This enabled improved probing, fewer assumptions, avoidance of premature interpretation, and an accentuated sense of curiosity during interviews.
Furthermore, SWITCH synchronizes labeling reactions to improve probe penetration depth and uniformity of staining.
The increased refrigeration power available with this more complex cycle improves probe effectiveness by reducing the number of probes and the time required to treat large tissue masses.
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