Although advances in surgical resection, the use of radiotherapy, and, predominantly, improved medical therapies have led to incremental improvements in median survival, few options exist for the management of recurrent or resistant disease.
The concurrent chemoradiotherapy with PF achieved improved disease control, predominantly of regional disease, compared with chemotherapy followed by radiation.
Replacement of vigabatrin by levetiracetam improved neither seizures (predominantly of myoclonic type) nor EEG pattern, whereas implementation of valproate finally led to a significant reduction of seizure frequency.
SVF injection predominantly improved vascular peripheral manifestations such as Raynaud's phenomenon severity, DUs outcome and hand pain, the latter being in major part related to chronic vasospasm and DUs.
Using pressure volume analysis, it was shown that preventive sildenafil increases contractility, reduces dilatation and attenuates the decline of spontaneous exercise, but leaves diastolic function unchanged [ 16], whereas in established RV pressure load, sildenafil treatment predominantly improved diastolic dysfunction, with a small effect on contractility [ 44].
The sensitivity of the DPV measurements was significantly improved by using a predominantly hydrogen-terminated BDD electrode obtained by a cathodic pretreatment.
Child road safety has predominantly been improved due to higher seat belt use and many implemented local safety measures such as campaigns and physical safe routes to school projects.
The developed approach and education of GPs has improved the diagnostics of predominantly antibody deficiencies in adults in Moscow.
Similarly, dietary counseling, food fortification, and nutritional supplementation were found to have positive effects on weight gain in undernourished patients with COPD [ 241, 242] but improved weight gain was predominantly due to increased fat mass.
The experimental site was a uniformly flat improved pasture, which consisted predominantly of smooth meadow grass (Poa pratensis) with smaller proportions of meadow fescue (Festuca pratensis), white clover (Trifolium repens), tussock grass (Deschampsia caespitosa) and couch grass (Agropyron repens).
