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Motivated by these observations, we propose a hybrid statistic that draws on both of these procedures so that the resulting test statistic has improved power in all situations; that is, the proposed statistic is more likely to detect a dose-related trend, if it exists, than is the poly-3 survival-adjusted CA trend test.
Using simulated data based on real data from the HapMap project, we show that PLS-based MLAS are simple to implement, and generally provides improved power in diseases genes mapping relative to tagSNPs-based MLAS, PCA-based MLAS and TSM-based MLAS.
Our method showed an improved power in mapping QTLs with non-normal phenotypes.
LIMMA uses an empirical Bayes method for improved power in designs which only include a small number of arrays [ 23].
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In particular, slow BR rate has been proposed as an endophenotype for bipolar disorder (BD) to improve power in large-scale genome-wide association studies.
In the framework of LCA, RIL can be used to greatly improve power in estimating non-additive genetic effects.
Imputed genotypes, generated with these methods, have been used, successfully, to improve power in association analyses [5], [14], [15], [16], [17], [18], [19], to facilitate meta-analyses, and to replicate significant findings in follow-up studies [6].
Both strategies, selecting the most likely genotype and selecting the posterior distribution of all possible genotypes, have demonstrated the capacity to improve power in follow-up association analysis [5], [6], [16].
The edgeR algorithm uses an empirical Bayes analysis to improve power in small sample sizes [ 19- 21].
This has been shown to improve power in other methods [ 11].
This indicated that IMP-WFDR can greatly improve power in detecting differentially expressed genes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com