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Possible benefits include: improved localisation of parenchymal consolidations (anterior versus posterior), detection of pneumothorax or pneumomediastinum patients in the supine position, verification of the correct position of drains and lines, differentiation between pleural effusions and consolidations, and other applications.
In addition, software-based image fusion improved localisation of tumour lesions [ 26].
In RA this approach has demonstrated improved localisation to sites of inflammation by measuring increased levels of fluorescence in inflamed paws with a fluorescently labelled PEGylated anti-TNFα agent compared to a non-PEGylated TNFα inhibitor [ 53].
Routine use of single-photon emission computed tomography (SPECT) and particularly of hybrid SPECT/computed tomography (CT) has significantly improved localisation of tumour sites and evaluation of somatostatin receptor (SSTR) expression, which is important for predicting the likelihood of response to somatostatin analogues (SSA).
The aim of this study was to use the improved localisation of fMRI in conjunction with EEG to investigate the vMMN response to simple visual object change detection without the potential confounding effects of cognitive load.
Together with improved localisation techniques, the ability to acquire signal from smaller voxels should lead to a better separation of tumour and normal tissue, and future studies might be able to generate enough metabolic information to provide both the diagnostic and prognostic parameters required by the clinician.
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Furthermore, the scatter fields correspond to a well-defined volume within the material, which enables volume imaging, improves localisation and has the potential to increase the detection rate by increasing the specificity of a system (Luggar and Gilboy 1999).
As they can depict anatomy better than the DWI images, the T1W and T2W images are especially useful in improving localisation of the lesion and assessing whether spurious DWI high signals mimicking possible cholesteatoma actually lie within or outside the post-operative middle ear cleft (Figs. 7 and 12).
However, the significant improvement in interobserver agreement between the three observers refutes the above line of reasoning and serves to validate the argument that the improved confidence among the three observers was a reflection of improved anatomical localisation by F-FDG PET/CT in real terms.
Integrating anatomic and functional information potentially allows improved lesion localisation and characterisation.
Enhanced binding to endothelial cells also led to improved tumour localisation of endostatin.
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