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Intracoronary delivery of an Ad vector encoding AC6 into a large-animal model of HF improved left ventricle function and attenuated deleterious left ventricular remodelling.
Several clinical studies have found that reduction of LVH leads to improved myocardial ischemia, improved systolic contractility, and improved left ventricular filling, reduced incidence of atrial fibrillation, and ventricular arrhythmia (6).
In mice with experimental MI, treatment with allopurinol slowed down subsequent left ventricular remodeling (dilation, hypertrophy, and interstitial fibrosis), resulting in substantially improved left ventricular function.
Epicardial application of HA-blood hydrogels improved left ventricular ejection fraction following myocardial infarction (p = 0.01).
Harmonic imaging improved left ventricular endocardial border delineation over fundamental imaging (superior: harmonic = 71.1%, fundamental = 18.7%; similar: 10.2%; P <.001).
However, there are also opposite findings demonstrating improved left ventricular function after CPB in experimental animals [13].
These materials have improved left ventricular (LV) geometry and ejection fraction, yet there remain concerns that biomaterial injection may create a substrate for arrhythmia.
In the Congestive Heart Failure Survival Trial of Antiarrhythmic Therapy (CHF-STAT), amiodarone lowered the frequency of AF development and improved left ventricular ejection fraction over time.
In an open-chest model of acute infarct, epicardial delivery of hepatocyte growth factor (pCK-HGF-X7) gene improved left ventricle (LV) function.
The isometric shoulder strength training more effectively improved left side shoulder abduction strength (p <.026), but no major differences were found for the other strength measurements.
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