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The subsequent addition of low-grade suction improved its efficacy [ 7].
In addition, specific strategies that reinforced the aims of our intervention over time may have improved its efficacy [ 24].
Several modes of therapy, including interferon- α, hydroxyurea, cytosine arabinoside, and allogenic stem cell transplantation, were applied in CML treatment, but introduction of imatinib mesylate (imatinib, Gleevec, STI 571) and other tyrosine kinase inhibitors significantly improved its efficacy [ 4].
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Metoclopramide administered in high doses acquires the capacity to block 5HT3 receptors, which improves its efficacy but it has frequent side effects.
However, further improvement may help to improve its efficacy.
However, the activity of gemcitabine in pancreatic cancer remains modest and there is a clear need to improve its efficacy by combining it with other anticancer drugs.
Further studies to improve its efficacy and to compare it with existing salvage regimens are warranted.
The relative instability of endostatin may limit its usefulness as a cancer treatment; however, it has been documented that continuous infusion can improve its efficacy over bolus treatment (Kisker et al, 2001).
However, there continues to be a need for alternative docetaxel delivery systems to improve its efficacy.
A prolonged constant infusion (10 mg/m2/min) has been proposed as a way to improve its efficacy.
To improve its efficacy, TFV was combined with the nonnucleoside reverse-transcriptase inhibitor UC781 in a vaginal gel.
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