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More and higher quality data should lead to improved hypothesis testing and predictions, yet as the quantity and quality of the reporting data improve, predictions are needed less.
Systematic analysis of their taxonomic distribution together with their primary and predicted secondary structures allowed us to provide a coherent classification and to propose an improved hypothesis for the evolution of this superfamily.
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Moreover, HyBrow's ability to propose "improved" hypotheses is orthogonal to its conjecture validation mechanism, and is a property of many other systems (e.g., [17]).
Perhaps clustering of genes by expression pattern will yield improved hypotheses regarding shared regulation and function.
While model predictions need to be experimentally validated, models can substantially improve hypothesis generation and experimental planning.
We also considered new approaches that account for missing lineages [CorSiM and BAMM [ 43, 47], thereby improving hypothesis testing frameworks.
Then again, conservation data on the sequence level is very often available, and conservation of transcriptional modules [ 5] can help to improve hypotheses about transcriptional regulation.
We expect that the study of these differences will be fundamental in postulating, verifying and uncovering mechanisms of regulation, while simultaneously confirming or improving hypotheses derived through in silico predictions.
This method gives appropriate consideration of the skin-stiffener interactions based on a proposed improved mechanical hypothesis.
FT improved the hypothesis and drafted the manuscript.
Our estimates of harpaline divergence dates are a working hypothesis subject to the addition of more taxa, molecular data, improved phylogenetic hypotheses, and fossils yet to be discovered.
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