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Reports of improved healthspan in laboratory models [ 5] have spurred the commercialization of resveratrol supplements [ 6], which are marketed for improving health and preventing chronic disease in healthy populations, rather than treating existing disease.
Interestingly, our findings of improved healthspan and modest increases in lifespan are in contrast to whole-body overexpression of SIRT1, which has been shown to result in improvements in healthspan without affecting the longevity of transgenic mice (Herranz et al., 2010).
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Martin-Montalvo, A. et al. Metformin improves healthspan and lifespan in mice.
A deeper understanding of complex networks genetic, cellular, physiological, and social should position us well to improve healthspan.
Together, our data demonstrate that disruption of the beclin 1 BCL2 complex is an effective mechanism to increase autophagy, prevent premature ageing, improve healthspan and promote longevity in mammals.
Nóbrega-Pereira S, Fernandez-Marcos PJ, Brioche T, Gomez-Cabrera MC, Salvador-Pascual A, Flores JM, et al G6PD protects from oxidative damage and improves healthspan in mice.
Deciphering the molecular mechanisms and physiological implications of the oxidative stress response during CR will increase our understanding of the basic biology of aging and pave the way for the design of CR mimetics to improve healthspan.
Removal of senescent cells partly restores WAT mass and improves healthspan in mice with progeroid syndrome [ 33].
Supporting this notion, some of us found that eliminating senescent cells from progeroid mice improves healthspan (Baker et al., 2011).
It prolongs lifespan and healthspan even when started late in life and in mixed genetic backgrounds and improves healthspan (Harrison et al., 2009; Hasty et al., 2014).
The discrepancy between lifespan extension by FUdR at 20°C versus 25°C suggests that FUdR improves healthspan only under mildly proteotoxic conditions (25°C).
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