Sentence examples for improved genomes was from inspiring English sources

The completeness and degree of contamination of the improved genomes was estimated by determining the presence and number of copies of 105 conserved single-copy bacterial marker genes (Dupont et al. 2012).

An improved genome Walking approach was used in order to sequence the remaining adjacent genes of the cluster.

The integration of proteomic data into a nucleotide database translated in the six reading frames, in order to improve genome annotation, was first proposed by Yates and co-workers [ 12] and has subsequently been applied at a large genomic scale by many research groups [ 3].

The tenuousness of therapeutic options for schistosomiasis, together with better knowledge of the molecular and biochemical idiosyncrasies of the parasite, and improved genome sequence information, are spurring increased investment in target discovery and validation [8], [17].

The validity of utilizing CGH and bioinformatics to improve genome annotation is well established [ 12- 14, 26].

The improved genome sequence of CPI 3.0.3 was deposited in the DDBJ/EMBL/GenBank database (accession number AHGY00000000.2).

For these reasons we selected the type strain N. punctiforme ATCC 29133 for resequencing and reannotation with the assumption that an improved genome sequence and annotation would be of significant value to the scientific community.

After improvement using Pilon, mapping Sanger sequencing reads of regions evidencing abnormal coverage and/or gaps, mapping of the filtered 454 Roche FLX data set (253,532 single reads) and manual curation, the final improved genome draft of Pseudomonas sp. M1 was obtained in 4 contigs organized in 1 scaffold, with 21 unknown nucleotides (N's), 7 SNVs, 5 indels, and a total size of 6,982,449 bp.

The accuracy of the niche map will likely improve as new sequenced genomes are added.

Nonetheless, the results presented here demonstrate the promise of leveraging population genetic data to detect selective constraint, an approach whose power will improve as more human genomes are sequenced.

In addition, since we estimated the parameters for different species based on the complete genomes currently available, the accuracy of the model can be improved when more complete microbe genomes are finished in the near future.