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Scores for physician's global assessment and total active joints improved from baseline, and improvement was maintained for the duration of the study.
Outcomes, calculated by repeated measures ANOVA, improved from baseline until week 16, with maintenance or further improvement until week 52.
Forty-three D&I research competencies were assessed; all improved from baseline to 6 and 18 months.
Serum albumin improved from baseline to follow-up by a mean (95% confidence interval) of 0.20 g/dL (95% confidence interval, 0.04 to 0.30; P =.001).
Stool consistency also improved, from baseline to Week 3 and Week 6, by more than 1 point on Hansen's stool consistency scale.
Specifically, 12 of 20 (60%) dogs improved from baseline when treated with Harmonease, whereas only 5 of 20 (25%) improved on placebo.
One year jeopardy index in surgery patients was 14.1+/-11%, 46.6+/-20.3% improved from baseline.
Visual function improved from baseline to follow-up and was generally favourable.
CGI-S was similarly significantly improved from baseline to weeks 2 and 4, but not week 8.
Condition-specific quality of life and bleeding scores were significantly improved from baseline at 6 months in both groups with no significant differences between them (Table 3).
Visual acuity improved from baseline > or =15 letters in 26% (day 98) and 45% (day 210) of subjects initially randomized to and continuing on ranibizumab, respectively, and areas of leakage and subretinal fluid decreased.
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