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OBJECTIVES Given the involvement of a variety of neural systems in the circuits of addiction, combination therapy may offer improved efficacy for successful smoking cessation beyond single treatments alone.
Preclinical studies have demonstrated improved efficacy for MM-302 relative to untargeted PLD [4,6] and quantitatively characterized the relationship between HER2 antigen expression level and MM-302-mediated doxorubicin delivery [5].
Some of these may demonstrate improved efficacy for established applications such as in the treatment of diabetes, or be suitable for exploiting new therapeutic opportunities such as in oncology.
Replication-competent retroviral vectors have achieved dramatically improved efficacy for in vivo cancer gene therapy and genome-free retroviral vectors expressing different kinds of antigens have proven excellent as immunogens.
A randomised phase 2 study failed to demonstrate any improved efficacy for lomeguatrib/temozolomide, nor any responses in patients treated with the combination after progression on temozolomide alone (Ranson et al, 2007).
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Qualitative impressions from group leaders suggested that slower pacing and increased rehearsal of skills may improve efficacy for immigrant parents unfamiliar with skills introduced in PT.
Thus, inhibition of Bcl-2 function and restoration of p53 simultaneously represents a promising strategy to overcome drug resistance and improve efficacy for the treatment of p53-mutant pancreatic cancer.
Thus, simultaneous inhibition of Bcl-2 function and restoration of p53 represents a promising strategy to overcome drug resistance and improve efficacy for the treatment of p53-mutant gastric cancer.
Despite the high efficacy of current treatments, EGFR inhibitors hold promise in two important ways: (1) to further improve efficacy for patients at risk for recurrence and (2) to decrease treatment-related toxicities by replacing more toxic cytotoxic drugs without jeopardising survival.
Activation of mucosal immune responses may provide improved efficacy of vaccination for P. aeruginosa during both acute exacerbations and chronic infection.
Laboratory and field studies have shown improved efficacy of these preparations for both individual and mass protection.
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CEO of Professional Science Editing for Scientists @ prosciediting.com