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The EPR effect implies improved efficacy.
Furthermore multi-target ligands often possess improved efficacy [1].
Prior research has suggested improved efficacy with the use of ultrasound prior to paracentesis [3, 4].
Taxane and antimetabolite doublets have improved efficacy compared with single agents.
Pharmacokinetic (PK) parameters like C2h have improved efficacy of immunosuppressive therapy.
Moreover, the compound has improved efficacy in a hedgehog/smoothened signaling mouse pharmacodynamic model.
The current work presents significantly improved efficacy of rhIL-11 via knowledge based re-designing process.
Lenalidomide is a thalidomide analogue, designed to have improved efficacy and tolerability over the parent drug.
Several mechanisms may contribute to improved efficacy.
Modification of dopamine by an alkanoyl group increased cellular uptake and significantly improved efficacy of protection.
We also propose that the design of CRAds should consider stromal cells as a potential target for achieving improved efficacy.
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