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However, based on data presented in this manuscript, we conclude that in the context of simultaneous PET/MR, improved dose response studies and in particular improved MR-derived AC algorithms are needed prior to its utilization for cancer staging.
This study has demonstrated the formulation of a novel ibuprofen polymer conjugate which exhibited improved dose distribution and pre-compression characteristics as well as controlled and extended-complete release profiles – a potential drug delivery strategy for poorly soluble drugs.
Dose imaging detectors based on gas electron multipliers (GEMs) are capable of providing high sensitivity, improved dose measurement linearity, position resolution, fast response and accurate characterization of depth-dose distributions.
Improved dose individualization and avoidance of or reduction in the severity of toxicity would assist in maintaining dose intensity.
This capacity for improved dose distribution affords considerable opportunity to reduce the overall toxicity profile associated with radiation therapy.
Modern techniques such as intensity modulated radiotherapy (IMRT) offer improved dose conformality even for long and complex shaped volumes.
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These and other studies of warfarin have even led to an improved dosing algorithm with improvements over the traditional clinical algorithm (International Warfarin Pharmacogenetics Consortium et al., 2009).
Pharmacogenomics, or using genetic variants to determine how a patient will respond to a particular drug, has been a mixed success such testing has not improved dosing for the blood thinner warfarin, for example.
Genotyping for these polymorphisms will probably not lead to an improved dosing strategy for optimizing exposure early after transplantation.
Using a 6 MV flattening filter free (FFF) beam improves dose enhancement compared to a standard 6 MV beam.
Intensity modulated proton therapy (IMPT) holds the potential to improve dose delivery and spare non-target tissues.
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