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When combined, the SIC and SF-36 together had improved discrimination for mortality (AUC = 0.74, p-value for difference in AUC < 0.005).
A new multivariable CPR (NEWS-HAZARD) combining coded history with physiological and blood parameters improved discrimination for in-hospital mortality.
The addition of the risk scores to the model of clinical risk factors modestly improved discrimination for T2DM by 1.6% in the case-control study and 2.9% in the prospective study.
Including a marker for a recent hospital admission resulted in a slightly improved discrimination for each Charlson derivation (p<0.0001).
Adjustment for the number of comorbid conditions compared to adjusting for the presence or absence of each condition/chapter did not result in improved discrimination for the ICD-10 chapters (Χ1 = 0.11, p = 0.743), FCI (Χ1 = 0.37, p = 0.544) or the six frequent chronic conditions (Χ1 = 1.21, p = 0.271).
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Inclusion of both Cumulus and ImageJ percent density readings jointly into the same model did not improve discrimination (for example, AUC=0.65 when readings from the two methods were examined in combination with other risk factors).
The addition of fibrinogen (along with urine albumin-creatinine ratio, ACR) to standard clinical and laboratory risk factors improved discrimination of a multimarker model for prediction of CVD events [ 12].
Similarly, for the validation set, the TTC10 model also improved discrimination: AUC = 0.55 for BCRAT alone, 0.79 (95 % CI 0.70 0.87) for BCRAT combined with TTC10, and 0.80 (95 % CI 0.71 0.89) when TTC10 is used alone (Fig. 4c).
Multilocus variable-number tandem-repeat analysis (MLVA) of these isolates improves discrimination of disease clusters for this pathogen, but even this tool assigns 30% of isolates to a single MLVA type.
ICA was then applied to the three most significant PCA components, determined by kept variance, to extract the independent maps of each sample, for improved discrimination.
When comparing FFRCT with CCTA stenosis for diagnosing obstructive CAD, FFRCT demonstrated improved discrimination with area under the ROC 0.81 for FFRCT and 0.68 for CCTA (P < 0.001).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com