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They had dramatically improved cure rates using a protocol called "directly observed therapy" to administer antibiotics.
The improved cure rates in our series may be the result of judicious patient selection rather than technical prowess.
While preclinical and early clinical trials suggested specific integrin targeting as a promising therapeutic approach, clinical trials failed to deliver improved cure rates up to now.
If true for neuroblastoma, improved cure rates may only be achieved via identification and therapeutic targeting of the neuroblastoma tumor initiating cell.
In contrast, implementation of effective treatment, such as artemisin-based combination therapy, has improved cure rates, decreased the gametocyte carriage and, therefore, resulted in a reduced transmission in low endemic areas [34], [35].
Even though our sample size was limited and final 24-month treatment outcomes are needed to definitively demonstrate the effectiveness of this strategy, our high rates of culture conversion and lower mortality rate pave the way for improved cure rates in MDR-TB and HIV co-infection, even in rural, resource-limited settings.
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Because there is widespread misunderstanding of the nature of clinical trials and the enormous potential they offer for improving cure rates and long-term survival.
The incorporation of those targeted treatments into the traditional therapeutic paradigms for neuroblastoma represents an important advance toward improving cure rates.
In the case of the latter, it promises to reduce the treatment duration (from two years to six months) and its cost (from $2,000 to $100), simplify it (pills-only, no injection required) and improve cure rates.
However, stearic acid-treated nano ZnO is very less effective in comparison to Si-69-treated nano ZnO in improving cure and mechanical properties of SBR vulcanizate.
Wide resection margins, in comparison with marginal resection, have been shown to decrease the recurrence of infection and improve cure rates [20, 21, 22].
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CEO of Professional Science Editing for Scientists @ prosciediting.com