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Alternatively, increased AURKA-CN may predict for improved benefit from chemotherapy by rendering the cells more susceptible, due to abnormal cell divisions.
Lung cancer treatment has recently moved toward a customized approach based on the molecular characteristics of tumors: patients with EGFR mutations may show improved benefit from EGFR tyrosine kinase inhibitors (TKIs; e.g., erlotinib and gefitinib), and those with ALK translocations from ALK inhibitors (e.g., crizotinib).
We observed a significantly improved benefit from tamoxifen in patients carrying the CYP2D6*4 allele and/or patients homozygous for SULT1A1*1 (P = 0.018), compared with patients homozygous for the CYP2D6*1 and carriers of the SULT1A1*2 allele (Fig. 3).
Furthermore, in light of the findings from several studies suggesting that 5-FU negatively affects outcome for microsatellite unstable tumours (Barratt et al, 2002; Ribic et al, 2003; Kim et al, 2007), the herein observed association between SATB2 expression and MSI status fits with the improved benefit from adjuvant treatment seen for patients with SATB2 high tumours.
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More importantly, the stability of the G@CuNP/G@Cu substrate is improved, benefiting from that graphene layer can act as the passivation layer to inhibit the surface oxidation of the Cu nanoparticles and Cu substrate.
Thus an even more fundamental challenge for carnivore conservation will be to build community tolerance for predators by reducing the need for retaliatory predator control and by improving benefit sharing from well managed trophy hunting [15].
Combination strategies in the first-line treatment have been studied most to improve the benefit from EGFR TKI monotherapy and delay the occurrence of resistance.
The LCP did require patients to be regularly monitored for any sign that they might improve and benefit from treatment to reverse the cause.
In order to improve the benefit from such combinations of mechanical and pharmacological measures, new mechanical devices for DVT prophylaxis are being developed.
In kinematic position estimation, a Kalman filter procedure is often used to provide improved solution benefiting from the history information.
"The profitability of our retail and services businesses improved strongly, benefiting from a successful holiday season," Mr. Martinez said in a statement.
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