Sentence examples for improved affinity to from inspiring English sources

The isolated clones exhibited improved affinity to these illicit drugs, yet maintained low cross-reactivity to over-the-counter drugs.

With compound 1b, a new ligand with a twofold improved affinity to the best so far known d-GalNAc was identified.

The flow cytometric assay was also used to screen a saturation mutagenesis library of Bak 72 87) variants for improved affinity to Bcl-xL.

Compared to the DOTA ligand, the DOTAGA derivatives showed higher hydrophilicity (logP = -3.6 ± 0.1 and -3.9 ± 0.1 for 68Ga and 177Lu, respectively) and improved affinity to PSMA resulting in an about twofold increased specific internalization of the 68Ga- and 177Lu-labelled DOTAGA analogue.

The additional P′ S′ interactions, relative to those of an exo peptidyl epoxide of the same P3 P1 sequence, significantly improved affinity to the enzymes papain and cathepsin B, but also changed the mode of inhibition from active-site directed inactivation to reversible competitive inhibition.

One prediction of the NES-conformer selection model would be that NESs with favorable conformations exhibit improved affinity to Crm1.

Directed evolution identified two point mutations that improve affinity to 180 pM.

To improve affinity to Aggrus, we performed phage display screening.

Addition of the aromatic moiety also showed a stacking interaction with conserved residue His, thus potentially improving affinity to both domains with a subsequent slight decrease in N-selectivity compared with parent molecule.

The A2, A11, and C5 minibody variants all demonstrated improved affinity compared to the parental (P) minibody and were ranked as follows: A2 > A11 > C5 > P.

With such an approach, these composite layers can be designed to have improved affinity for cells and to exhibit increased gene transfer efficiency over that of conventional lipid transfection reagents.