Furthermore, [natGa]NOTA-pentixafor had already shown improved affinity towards CXCR4 in a previous study [21].
The generated PI3Kα mutants exhibit significantly improved affinity for selective ATR inhibitors in multiple chemical classes.
The derivatives with cyclized (rigidified) elements in the spacer do not have a much improved affinity [35].
The isolated clones exhibited improved affinity to these illicit drugs, yet maintained low cross-reactivity to over-the-counter drugs.
The variant DigA16/19, which carries several new mutations, exhibits clearly improved affinity for digoxigenin, with KD=12.4 nM.
This hybrid coating increased the wettability and surface roughness of carbon fibers, which led to improved affinity between the carbon fibers and epoxy matrix.
With compound 1b, a new ligand with a twofold improved affinity to the best so far known d-GalNAc was identified.
Binding and functional studies revealed that these hydrogen-bond donor containing compounds exhibit improved affinity and selectivity for the α7 nAChR subtype and demonstrate partial agonism.
HwTx-IV and mHwTx-IV exhibited weak affinity for lipid membranes, whereas gHwTx-IV showed improved affinity for the model membranes studied.
The flow cytometric assay was also used to screen a saturation mutagenesis library of Bak 72 87) variants for improved affinity to Bcl-xL.
Moreover, we improved affinity by mutating two residues in heavy-chain complementarity-determining regions (CDR), on the basis of the crystal structure of the antigen antibody complex.
