Sentence examples for improved accumulation from inspiring English sources

The results demonstrate that DOX-loaded POEUs nanoparticles show a prolonged blood circulation time and improved accumulation in solid tumor, leading to enhanced therapeutic efficacy.

Caplostatin exhibited improved accumulation in tumor vasculature due to passive targeting and had reduced toxicity compared to TNP-470.

This delivery system improved accumulation of carrier-siRNA complexes in the tumour tissue.

Long blood circulation time can increase the needed in vivo availability and is therefore an important factor to improve accumulation in tumor tissue.

Tight sandstone gas reservoirs are also found adjacent to widely distributed source rocks and are characterized by short-distance seepage diffusion and non-Darcy seepage migration processes, which can improve accumulation efficiency (Zou et al. 2012).

Additionally, incorporation of tumor-specific ligands onto particle surfaces is commonly used to improve accumulation of nanoparticles in tumor tissue.

Our future goals are to further modify the MNPs to improve accumulation in tumors relative to other tissues and organs, and to test these improved MNPs in treatment of a preclinical metastatic model.

Targeting the endoplasmic reticulum (ER) has been suggested as a way to improve accumulation levels, due to either the low proteolytic activity in the lumen or the higher folding ability of ER resident chaperones [ 58, 59].

Among these, oil body-targeted oleosin fusion proteins and ER-targeted fusion proteins with elastin-like Polypeptide (ELP), hydrophobin I (HFBI) and Zera® have been of particular interest as they improve accumulation and stability of recombinant proteins in plants, and assist in the subsequent purification process of the recombinant proteins [ 12- 18].

Although CMVinII E 6 and 8 variants gave slightly more active E1 in most experiments, CMVarI and II variants offers advantages in ease of use (e.g. no need to add the inducer) and thus, two additional approaches to improve accumulation of the desired protein product were investigated.

The addition of HFs or HFs/threads improved matrix accumulation in the central core region.