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Since depletion or suppression of one of several types of effector cells does not significantly improve the severity of the disease, combined TCR-based immunotherapy should be considered as a primary therapy for T cell-mediated autoimmune diseases.
Consequently, our results raise the central issue of whether the normalization of blood glucose levels in humans can significantly improve the severity of sleep apnea.
Significant increases in urine output and changes in body weight were observed with all doses of conivaptan compared to placebo, but conivaptan did not improve the severity of respiratory symptoms.
Pioglitazone and rosiglitazone are known to activate peroxisome proliferator-activated receptor gamma (PPARγ) and it has been suggested that a reversible defect in PPARγ signaling in Cftr-deficient cells could improve the severity of the CF phenotype in mice.
Several other studies have also shown that selective intracerebral NO injection, [ 192] intraventricular NO injection [ 193], and systemic nitrite infusions can improve the severity or decrease the incidence of vasospasm in experimental and clinical studies [ 189].
However, to our knowledge, no review has been conducted to assess the comparative effectiveness of different injection approaches to improve the severity and function of the hands affected by carpal tunnel syndrome.
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To compare the efficacy of two regimens (21 active pills + 7 placebo pills vs. 24 active pills + 4 placebo pills) of combined oral contraception (COC), both containing 20 μg of ethinyl E2 and 3 mg of drospirenone, in improving the severity of pure menstrual migraine without aura.
Moreover, removal of sFLT-1 from the maternal circulation by apheresis improves the severity of the disease and consequently prolongs the duration of pregnancy [ 13].
APC improved the severity of pancreatic tissue histology, superinfection rates and serum markers of inflammation during the course of acute necrotizing pancreatitis.
These results indicate that bilateral GPi-DBS is effective in improving the severity of dystonia in both the short (2 6 months) and long-term (9 15 months).
Conclusions A brief behavioural sleep intervention modestly improves the severity of ADHD symptoms in a community sample of children with ADHD, most of whom were taking stimulant medications.
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