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The ambitious engineering aims of synthetic biology are rapidly becoming a reality, based on advances in our ability to edit genomes, identify and optimize biosynthetic building blocks, rapidly create libraries of pathways and novel compounds, and to debug and improve the engineered systems.
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The findings indicate that bicarbonate amendment may be useful in improving the engineered bioremediation of uranium in aquifers.
Following up from the report of artemisinic acid manufacture in the engineered yeast [ 7], we evaluated and further improved the engineered yeast as a microbial host to produce the drug precursor artemisinic acid.
In addition, to improve the final engineered product, we utilised Flp recombinase to remove the unc-119 selection marker, in somatic cells, producing clean knockouts in these cells.
Knowledge about the wave attenuation mechanism of ITP improves the engineer's ability to make more cost-effective design.
Geosynthetic reinforcement and prefabricated vertical drains (PVDs), both separately and in combination, have substantially improved the engineer's ability to cost-effectively construct embankments and fills over difficult and soft soils.
Further, when challenged with 15 mM concentrations of either furan aldehyde, the ability to eliminate furfural or 5-HMF from the culture medium was significantly improved in the engineered strain.
Thus, it is essential to utilize physiological stimuli to improve the quality of engineered constructs.
These results provided a new insight into the metabolic engineering of C. glabrata for acetoin production, and offered a potential platform to improve the performance of engineered pathways.
Finally, guidelines for designing two-layer shells were proposed to improve the performance of engineered protective systems undergoing similar structural and loading conditions.
By enabling reproducible and controlled changes of specific environmental factors, bioreactor systems provide both the technological means to reveal fundamental mechanisms of cell function in a 3D environment, and the potential to improve the quality of engineered tissues.
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CEO of Professional Science Editing for Scientists @ prosciediting.com