Sentence examples for improve the compound from inspiring English sources

In order to improve the compound we first studied the effect of the addition of hydrogen bond donors and acceptors to the ortho- and meta-positions of the phenyl ring (C-ring), which could form additional interactions with the protein (Fig. 3).

Based on the crystallographic studies of diarylpyrimidines (DAPYs), we embarked on incorporating the hydrophilic piperidyl or morpholinyl group into the known DAPY derivatives bearing the pyridine moiety as a core structure, with the double aim to exploit additional interactions with the HIV-1 NNRTI binding pocket (NNIBP), as well as to improve the compound solubility.

For target compound analysis, a flow injection analysis (FIA) was carried out to determine the fragmentor setting to improve the compound response.

In order to improve the compound-target ratio, targets with only one compound were removed from the database resulting in a dataset of 597 compounds covering 91 targets.

Mn addition has improved the compound integrity on cycling and also increased the overall electrochemical performance of the electrode materials.

The in vitro stability assay revealed that transformation of GLA to Mannich base type derivatives improved the compound stability in rat plasma.

Furthermore, modification of asiatic acid functional groups have been carried out with the aim of improving the compound's potential as a hepatoprotective agent [9, 10].

This derivatization also improved the compound's thermo-oxidative stability, measured using pressurized differential scanning calorimetry (PDSC) and thin-film micro-oxidation (TFMO) testing.

Therefore, integrating the biological information from different cell lines in a single PGM model improves the compound sensitivity prediction on the NCI60 panel over the QSAR models, and even more so in cases where activities across cell lines show less of a correlation.

It is shown how the addition of an intermediate layer can improve the whole compound and which properties it should have.

Because 2-ME has a low bioavailability and rapid in vivo metabolism, 2-ME analogues were in silico-designed in our laboratory to improve the parent compounds' pharmacokinetics.