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These nanosystems can control the drug-releasing pattern temporally and spatially and can improve the accumulation of chemotherapeutic agents in MDR tumors or cells.
Targeting ligands such as vitamins, peptides, and antibodies can improve the accumulation of nanoparticle-based therapies in tumor tissue but must be optimized to allow for intratumoral penetration.
Stimulus-coupled drug delivery can control the drug-releasing pattern temporally and spatially, and improve the accumulation of chemotherapeutic agents at targeting sites.
To improve the accumulation, we examined cell wall binding protease (wprA)- and/or sigma D (sigD -deficient mutantsigD -deficientprE and AprA protease-deficient mutantsandhost stralso.
In conclusion, the present study provides a basis for the elucidation of the role of IiPALs genes in the biosynthesis of phenolic compounds, which will help further metabolic engineering to improve the accumulation of bioactive components in I. indigotica.
In vivo biodistribution and anti-tumor effect were determined in H22 tumor-bearing mice, and the results demonstrate that the acid-labile MASCS nanogels can significantly prolong the blood circulation time of DOX and improve the accumulation in tumor areas, leading to higher therapeutic efficacy.
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In the present study, the A1B3 treatment (full light and Muchuan provenance) was the most effective way to improve the accumulations of total and selected flavonoids because it resulted in the highest leaf biomass production.
Compared to the control treatments, P-compost improved the accumulation of the three essential minerals in alfalfa leaves (N, P and K), except K in 2011 which was slightly decreased.
In the present study, aLTS and tLTS treatments improved the accumulation of SP and FAA and activity of carboxypeptidase but decreased activity of endopeptidase, indicating that carboxypeptidase was critical to cleave peptide bonds for FAA.
MeJA is well-known for improving the accumulation of various secondary metabolites [ 23- 25].
Hydrophobins were also demonstrated to be useful in improving the accumulation of fusion partners [ 24].
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