Females were oversampled to improve statistical power for sex-specific analyses.
However, translating a reduction in COV to improve statistical power requires additional assumptions, e.g., regarding the potential treatment effect [50].
Some studies have combined patients with different pathological diagnoses to improve statistical power however it is highly likely that the dose response will be pathology dependent [13].
To improve statistical power, we considered men and women together.
Another feature of the proposed method that can improve statistical power is the ability to perform multivariate association tests.
The VL measure was first evaluated in SPs and SCs combined to improve statistical power (sample size) [28], [35].
This strategy, by excluding non-informative rare variants from grouping, is expected to improve statistical power when neutral variants comprise a substantial large proportion of the total variants.
We aimed to evaluate whether, and to what extent, incorporation of results from these prediction algorithms can improve statistical power for detecting disease associated rare variants.
In this study, aiming to improve statistical power of association tests in the presence of neutral rare variants, we propose two alternative strategies.
Another recently-published approach involves treating redundant probe sets as replicate measurements of the same gene in an attempt to improve statistical power in differential expression inference [23].
In this study, in order to improve statistical power of testing disease-associated rare variants, we proposed two alternative grouping strategies to the strategy of grouping total variants.
