Sentence examples for improve selectivity for from inspiring English sources

Several different conditions can be varied to improve selectivity for reversed-phase chromatography (RPC).

X-ray crystallography and structure-based drug design were used to improve selectivity for RARγ by targeting residue differences in the ligand binding pockets of these receptors.

Members of this series were designed to improve selectivity for MC4R versus the other melanocortin receptors, and to reduce the flexibility of the side chains.

Catalyst-enabled reduction of the working potential under CPA was found to improve selectivity for NO over high potential interferents, regardless of MPc.

Products amplified with NSI1 and NLB4 were reamplified with 58A1F and NLB4 as described previously to improve selectivity for fungal DNA contaminated with plant sequences [42].

Subsequent mutagenesis of the wild-type toxin can then further improve potency and strive to improve selectivity for a given VGSC isoform.

The spectroelectrochemical sensor combines in a single device electrochemistry, spectroscopy, and selective partitioning into a film, giving improved selectivity for applications that involve complex samples.

We note some areas for improvement, including increasing the rate of deacetylation and improving selectivity for a single HDAC isoform, which may be accomplished through future structural modifications.

Compound 6 showed improved selectivity for JAK1 compared to that of tofacitinib (IC50 11, 2.4 × 102, 2.8 × 103, and 1.1 × 102 nM for JAK1, JAK2, JAK3, and TYK2, respectively).

We further describe design strategies that utilize the ponatinib scaffold to develop two classes of inhibitors (CS and PN series), each with greatly improved selectivity for RIPK1.

Structure-based methods were used to design β-sulfone 3,3-piperidine hydroxamates as TACE inhibitors with the aim of improving selectivity for TACE versus MMP-13.