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Hence, a large randomized trial is certainly warranted in the near future to establish whether tocotrienol adjuvant therapy can significantly improve recurrence or mortality or both.
In a study analyzing 93 patients with vulvar carcinoma, a margin of more than 8 mm did not improve recurrence rate.
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We postulated that adjuvant treatment with imatinib would improve recurrence-free survival compared with placebo after resection of localised, primary gastrointestinal stromal tumour.
Long-acting somatostatin analogues (S-LAR) improve recurrence-free survival in patients with metastatic neuroendocrine tumor (NET) from gastrointestinal (GI) primary, but their impact on overall survival when combined with aggressive cytoreductive surgery is unclear.
However, it did not improve recurrence-free survival.
FOLFOX adjuvant chemotherapy has been shown to improve recurrence-free survival and overall survival by more than 20% and is nowadays considered a standard of care.
In the adjuvant FinXX trial [ 17], integration of capecitabine into an adjuvant regimen that contained docetaxel, epirubicin, and cyclophosphamide did not significantly improve recurrence-free survival compared with a similar regimen without capecitabine.
Post-operative systemic therapies (chemotherapy, endocrine therapy and more recently passive immunotherapy/targeted therapy with anti-HER2 monoclonal antibody) have been shown to improve recurrence-free and overall survival in patients with early breast cancer [ 3, 4].
We then performed this prospective, randomised phase 3 study to determine whether MFP could improve recurrence-free survival (RFS) over the Mf regimen in patients with GC after curative D2 resection.
Since transcriptome analysis only provides snapshots of the gene expression state in cells constituting the tissue at study, clear improvements in diagnostic accuracy or clinical endpoints (e.g., improved recurrence free survival) must be objectively shown before the results of such studies can be safely implemented in the clinical armamentarium.
Adjuvant endocrine therapy improves recurrence and survival rates, but has side effects and is inconvenient.
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