These genetic determinants of prognosis are important because they could improve prognostic models, aid selection of appropriate treatments, and suggest targets for new therapies.
The assay allows evaluating WT1 rs16754 polymorphism in diagnostic routine to improve prognostic information faster and without over-costing for diagnostic laboratories.
On the clinical side, collaborative multicenter trials designed to recognize the principal variables controlling therapeutic responses and improve prognostic indicators may enable tailoring devices, treatment schedules, and doses to the needs of the individual patients or diseases.
1) To assess the prognostic value of levels on admission and serial measurements of lipopolysaccharide binding protein (LBP) and procalcitonin (PCT) in relation to in-hospital mortality; and 2) to determine whether the addition of these parameters to severity scores (APACHE II and SOFA) is able to improve prognostic accuracy.
More accurate prognostic models should be developed; the inclusion of tumor genetic variants may improve prognostic models.
Multivariate analysis was performed including both PET/CT and CA-125 to determine if the addition of PET/CT to CA-125 would improve prognostic accuracy.
Nonetheless, the emergence of an increasing number of biomarkers may provide a new avenue with which to improve prognostic accuracy in a simple and rapid manner.
The GCPS was originally developed for general population surveys and primary health care to improve prognostic categorization and treatment decisions [34].
We showed how such computational integration can improve prognostic performance.
These methods allow researchers to identify genes that may not be necessarily highly-differentially expressed across control-case groups, but whose integration into computational predictive models can improve prognostic accuracy.
Can attaining a pCR improve prognostic outcome?
