Sentence examples for improve potency of from inspiring English sources

Molecular modeling was used to improve potency of the cyclohexylamine series.

In an effort to improve potency of the antagonists we synthesized over 200 derivatives and tested these derivatives in the 10T1/2 Super8xTOPflash reporter assay.

Structure activity relationship studies have subsequently attempted to improve potency of Lys-CoA and probe p300 catalysis.

It also demonstrates that SBCAMD is capable of improving potency of an inhibitor lead by nearly one order of magnitude, even for BoNTAe as one of the most challenging protein targets.

Lacking insight into the binding mode, initial attempts to improve inhibitor potency failed to improve potency, and synthesis of analogs was further hampered by the presence of a C C bond between the pyrrolidine and pyridine.

The engineering of cell-specific enhancers to improve potency and the development of two-step transcriptional activation (TSTA) approaches have significantly improved the efficacy of transgene expression.

Modifications to improve potency and water-solubility of 41F5 focused primarily on the 5-naphthalenyl group, the thiazole core, and the methylene linker between these two structural elements.

In a series of alkyl and electron withdrawing groups that had improved potency, introduction of trifluoromethyl and chloro groups meta and para, respectively, to the thiourea nitrogen was optimal (30, IC50 0.03 μg/mL).

None of the compounds showed improved potency over that of the parent compounds, with the relatively low potencies limiting the derivation of structure activity relationships.

Manipulation of the Zolpidem structure, notably, to structural isomers ("anagrams"), attains remarkably improved potency (5, MIC of 0.004 μM) and impressive potency against clinically relevant drug-sensitive, multi- and extensively drug-resistant Mtb strains (MIC < 0.03 μM).

These observations suggest an improved potency and therapeutic index of AR-42 that will be of key importance in the development of this agent, given the widely observed constitutional symptoms observed with this class of drugs.