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Canbolat et al. [ 27] proposed two approaches in order to improve permeation and dispersion of cells within the nanofibrous scaffold as well, so as to enhance the thickness of the electrospun mat.
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Based on observed and predicted results, wrapping CNTs by PSS improved permeation flux and dye removal efficiency of MMMs.
Moreover, it was the most beneficial formulation for improving permeation and diffusivity of Ofloxacin even after 16 h.
The optimized gel showed improved permeation profile with cumulative drug permeation of 26.262 ± 2.157%, and permeation flux of 0.059 ± 0.011 μg/cm2/h.
The significant extent of the skin penetration of the LNE formulation was most likely attributed to the fact that nanoemulsions provide superior skin hydration, which has been shown to be helpful for improving permeation effects [34].
There is sustained interest in sub-100 nm particles of poorly water-soluble drugs as such small particles offer improved permeation through various biological barriers and result in rapid onset of therapeutic action.
The addition of 1% (v/v) oleic acid greatly improved permeation of endoxifen over a 24-hour period [ 64].
Although the exact method of action of ethosomes remains unclear, ethanol is a well-known permeation enhancer, and mechanisms of these carriers in improving permeation are explained by their alcohol content as penetration enhancers.
Various permeation enhancers were also tried to improve the permeation of drug through sublingual mucosa.
KH and DKH did not improve ketorolac permeation but exhibited a sustained release behavior.
Knowledge of delivery system transport through epidermal cell monolayer is vital to improve skin permeation and bioavailability.
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