Sentence examples for improve imputation of from inspiring English sources

We examined if this categorization can be used to improve imputation of expression values.

Thus, the validation set helps improve imputation of the training set and vice versa.

Table  5 quantitatively shows that although the combined-breed scenario provides more diverse haplotypes in the reference population than the single-breed scenario, these non-conserved haplotypes would not contribute to improve imputation of purebred animals.

In an attempt to improve imputation for the small subset of poorly imputed SNPs in the QCed data, we excluded all SNPs with MAF<5% and, subsequently, also SNPs with MAF<10%.

Combining reference data from all populations helps improve imputation accuracy of low-frequency variants [ 36].

To improve imputation accuracy of rare variants, various approaches have been suggested, including increasing the sample size of the reference panel, using sequencing data from study-specific samples (i.e., specific populations), and using local reference panels by genotyping or sequencing a subset of study samples.

In particular, whole genome sequencing enables the generation of better reference panels to improve imputation quality and thus improve power of subsequent association studies.

Improvement in the genome-wide coverage and haplotypes of diverse populations in reference panels for imputation such as the 1000 Genomes Project [ 45] and the Haplotype Reference consortium (http://www.haplotype-reference-consortium.org/) will also improve imputation quality, especially for identification of low frequency disease variants.

Combining reference populations from different breeds did not improve imputation accuracy, which confirms the results on multi-breed imputation of Hayes et al. [ 28] and Erbe et al. [ 29].

The imputation of low-frequency and rare variants can be challenging compared with common alleles, and the availability of very large-scale reference panels can improve imputation performance.

Thus, denser markers will also help improve imputation AR.