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Such a detailed understanding may be required to improve efficacy and reduce side effects.
Fusion of cytokines to antibodies or antibody fragments allows for a targeted delivery and should, therefore, improve efficacy and pharmacokinetics.
In this regard, stimuli responsive nanoplatforms further favour combinatorial therapeutic approach that can considerably improve efficacy and specificity of treatment.
Recently, research efforts have focused on design of prodrugs for tissue specific delivery to improve efficacy and safety.
PHIS continues to be an invaluable tool in assisting hospitals in their everyday efforts to improve efficacy and performance.
To improve efficacy and reduce toxicity of treatment for children with acute lymphoblastic leukemia.Patients from all risk groups, including infants and those with T-cell disease, were treated between 1987 and 1991.
The ability to generate potent immunotherapies locally and transiently for the treatment of cancers is a promising strategy to improve efficacy and decrease off-target toxicities.
Future translation of this knowledge will facilitate the development of preclinical toxicity screening to significantly improve efficacy and safety of drug development and design.
Selective tumor targeting of oncolytic adenovirus at the level of cell entry remains a major challenge to improve efficacy and safety.
Within the context of HTS measurements, the assay should be easy-to-use and cost-effective to allow the interrogation of large chemical collections as well as reiterative screening for downstream explorations of structure-activity relationship to improve efficacy and optimize pharmacology of potential lead compounds.
The most potent compounds (1.2 1.3-fold the CQ on the W-2 strain) can be considered as promising 'lead compounds' to be further optimized to improve efficacy and selectivity against Plasmodia.
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