Sentence examples for improve delivery efficacy from inspiring English sources

Nanoparticles coupled with surface ligands or antibodies can localize to tissue expressing the associated receptors or antigens and improve delivery efficacy.

These recent trials in CXMDj utilised very high and frequent doses of systemically delivered antisense oligonucleotides; additional work, in particular, improving delivery, efficacy and reducing dose, frequency and the potential for toxicity is very important for similar systemic therapeutic trials in humans.

Modification of the surface of the liposomes may enable investigators to improve delivery and efficacy.

Since imatinib is known to inhibit PDGF-R β and decrease IFP in solid tumours, it has the potential to 'normalise' the tumour microenvironment and thereby improve delivery and efficacy of chemotherapeutic agents.

Other future projects will involve testing of different time points to study the duration of the RNA silencing effect and addition of targeting moieties to further optimize and improve delivery and efficacy.

In this regard, nanoparticle-based approaches by virtue of their unique nanoscale and physicochemical properties (e. g., multivalent drug delivery) have been shown to overcome the aforementioned challenges by providing means to improve delivery and drug efficacy.

Thus, our data indicate that the same mechanism of acquired pharmacoresistance might apply to other ALS therapeutics and that blocking P-gp and BCRP with elacridar or similar transporters' inhibitors might also improve delivery, and ultimately, efficacy, of other candidate drugs.

Attempts have been undertaken to improve delivery of TRAIL to target cells and its therapeutic efficacy [ 15].

Functional engineered particles including drugs and drug-loaded nanocarriers have been anticipated because they can improve drug delivery efficacy against target sites in the lungs or blood.

MTX-CS NGs can greatly enhance the solubility and improve the delivery efficacy of MTX due to the CD44 binding property of CS.

Targeted delivery offers a significant advantage for the local delivery of therapeutic payload and/or imaging contrast agents to a specific target site and promises to improve the delivery efficacy to the target tissue while minimizing the exposure to normal tissues.