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One pragmatic way to improve compound quality, while enhancing and accelerating drug discovery projects, is the ability to access a high quality, novel, diverse building block collection.
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The refined list of compounds could be used to improve the quality of compounds used in screening libraries in the pharmaceutical industry.
Our results demonstrate that low temperature maintenance can be used to boost the functional expression of some difficult-to-express cell surface membrane associated proteins such as the hERG channel, and significantly improve the quality of compound screening assays ranging from patch clamping to radio-ligand binding.
Using biological systems to make chemical compounds, Fuerst explains, can improve the quality of the compounds and reduce the cost.
David Smil and Yuri Bolshan performed compound quality control experiments.
99mTc-Labelled radiopharmaceuticals, compared with for example In-labelled compounds, may improve the quality of images and radiation safety for patients and the staff as a natural consequence of this isotope's physical properties.
In this paper, graph-based consensus clustering is used to improve the quality of chemical compound clustering by enhancing the robustness, novelty, consistency and stability of individual clusterings.
Spatial compounding aims to improve image quality through signal averaging, but speed-of-sound (SoS) and refraction errors can misalign the component frames and blur the compound image.
To improve the quality of prediction, we collected more than 5000 chemical compounds with anticancer activities.
It suddenly occurred to me that if you fashioned a thick block of concrete the precise shape of the backstage compound, and dropped it from a helicopter, crushing everyone below, you'd improve the quality of life on the planet by at least 3%.
The extractable bio-active compounds from medicinal mushrooms would enhance human's immune systems and improve their quality of life.
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