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Background Both metoprolol and carvedilol improve cardiac function and prolong survival in patients with heart failure.
Transplantation of healthy regenerative cardiomyocytes into the injured heart is effective option to improve cardiac function.
Mesenchymal stem cells (MSCs) significantly improve cardiac function mainly through the paracrine effects.
Cell sheet patches improve cardiac function in a patient with dilated cardiomyopathy.
Correction of this abnormality by gene transfer might improve cardiac function.
Optimization of CRT pacing parameters can further improve cardiac function, both acutely and chronically.
In principle, cardiovascular stem cells can improve cardiac function via de novo cardiomyogenesis, enhanced myocardial neovascularization, and prevention of post-infarct remodeling.
TGFβRI inhibition in an injured adult heart could both stimulate the autocrine/paracrine activity of survivin and inhibit Wnt in CPCs to mediate cardioprotection and improve cardiac function.
Cell therapy can improve cardiac function in animals and humans after injury, but the mechanism is unclear.
Several clinical studies have demonstrated that metoprolol and propranolol belong to one of the few classes of drugs that improve cardiac function and reduce mortality in patients with heart failure.
Other potential beneficial effects are the direct vasodilation of coronary arteries, which could improve cardiac function in this setting.
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