Exact(55)
Bioisosterism and scaffold hopping are key concepts in drug design and optimization, and can be defined as replacements of biologically active compound's fragments with other fragments to improve activity, reduce toxicity, change bioavailability or to diversify the scaffold space.
More research is needed to identify how best to improve activity levels in this patient population and whether improvements in physical activity are associated with improved health outcomes.
Nanotechnological strategies change a substance's properties and behavior in a biological environment and can potentiate the actions of plant extracts, promote sustained release of active ingredients, reduced the required dose, decrease the side effects and improve activity [ 4].
As observed for the methyl addition, the addition of the ethyl group did not significantly improve activity against most organisms; however, a slight but consistent 2-dilution improvement was observed in the activity against S. pneumoniae, which suggests an advantage to having combinations of alkyl groups more than 2 carbons.
This aim of such modification is to further improve activity and/or selectivity.
AtNit1 was subsequently optimized to increase expression and engineered to improve activity.
Similar(5)
DEA models help a DMU to detect its (in- efficiency and to in- efficiencyties, if necessand.
Think of those anxious middle-class parents that constantly fill their children's lives with improving activity.
June's price dip, he said "does not fundamentally change our view that house prices are likely to be firmer over the second half of the year amid improving activity.
While trading conditions in the housing market have improved, activity levels will remain constrained until the availability of mortgage finance increases particularly at higher loan to value levels.
Some derivatives exhibited greatly improved activity against erythromycin-resistant bacteria.
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