The investigators determined that 36,000 drivers improperly activated the higher rate at least once, and that about 3,000 drivers did it more than 100 times.
In one scenario, drug perturbation could, for example, improperly activate a protein that normally inhibits a particular kinase.
Therefore, Rac1 is essential for normal cell function; however, when improperly activated, it contributes to tumour cell growth, invasion, and angiogenesis [ 59].
In the case of hybrid inviability, the plant immune system is improperly activated in the absence of a pathogen attack because of the genetic incompatibility, which causes tissue necrosis similar to that observed during HR.
Important for peptide vaccine development, these results imply that T cells responding to the ineffective variants (like WMF) cannot be "rescued" or forced to respond to the tumor antigen with better adjuvants; they are not anergic or improperly activated, they simply express T cell receptors that interact poorly with the native tumor antigen.
Unattached or improperly attached chromosomes activate the SAC pathway and induce mitotic checkpoint complex (MCC) establishment including BubR1, Mad2 and Bub3[7].
Antidepressants are activating.
Activating Supporters Through Gamification.
In the second case, a woman being treated for breast cancer at the state's Downstate Medical Center in Brooklyn got three times the prescribed radiation for 27 days because a therapist programmed a computer improperly, a vital filter was not activated and therapists again failed to notice indicators on their screens.
When chromosomes are attached improperly, a signal of no tension is sensed to activate the spindle assembly checkpoint (SAC).
